Clinical Manifestation
Crigler-Najjar syndrome is manifested by severe, persistent jaundice, a condition in which
the skin and the whites of the eyes become yellow. This is due to excessive plasmatic levels of bilirubin (> 20 mg/dL, corresponding to approximately 342 umol/L, in Crigler-Najjar type I patients). Whether untreated severe jaundice may result in brain damage (kernicterus) with possible permanent effects. As results of brain damage clinical manifestations of kernicterus include hypotonia, lethargy, deafness, oculomotor palsy.
the skin and the whites of the eyes become yellow. This is due to excessive plasmatic levels of bilirubin (> 20 mg/dL, corresponding to approximately 342 umol/L, in Crigler-Najjar type I patients). Whether untreated severe jaundice may result in brain damage (kernicterus) with possible permanent effects. As results of brain damage clinical manifestations of kernicterus include hypotonia, lethargy, deafness, oculomotor palsy. 